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Geopolitics

The Week the World Admitted the Truth About America

“We are in the midst of a rupture, not a transition,” Prime Minister Mark Carney of Canada announced last week at the World Economic Forum in Davos, Switzerland. It was one of the most significant foreign policy speeches in years, sending shockwaves through the international community. He was describing a dynamic that’s been building for decades — what the scholars Henry Farrell and Abraham Newman call “weaponized interdependence” — that has now reached a tipping point. I asked Farrell on the...

Global
Healthcare

The first human test of a rejuvenation method will begin “shortly”

When Elon Musk was at Davos last week, an interviewer asked him if he thought aging could be reversed. Musk said he hasn’t put much time into the problem but suspects it is “very solvable” and that when scientists discover why we age, it’s going to be something “obvious.” Not long after, the Harvard professor…

Global
Culture

Comedian James McCann Destroys Triggernometry

James McCann is an Australian stand‑up comedian known for sharp satire, chaotic energy, and unfiltered commentary on politics and culture. | QUO: Business Phone System for Startups. Try QUO for free, PLUS get 20% off your first 6 months when you go to https://quo.com/TRIG Triggernometry is proudly independent. Thanks to the sponsors below for making that possible: - Get Huel’s full High-Protein Starter Kit with my exclusive offer of 20% OFF online with my code TRIGGER20 at https://huel.com/TR...

Australia
Healthcare

Ambience CEO Nikhil Buduma on AI in Clinical Workflows

a16z general partner Julie Yoo talks with Nikhil Buduma, CEO and cofounder of Ambience Healthcare, to discuss how AI is transforming clinical workflows. They cover the early days of deep learning, why Ambience started by running a medical practice before building a platform company, and what it takes to achieve high clinician adoption rates at major academic medical centers. They also dig into the challenge of building products when AI capabilities change every few months, the real ROI that's...

United States