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Healthcare

Can We Trust the FDA? Marty Makary on Science, Power & Patients

(0:00) Friedberg intros FDA Commissioner Marty Makary (3:21) Inside the 42 major FDA reforms in 10 months (7:51) The China Race: Winning back biotech leadership (13:14) Accelerating drug approvals safely, how to cut down on clinical trial timelines (33:13) Reshaping the failed Food Pyramid (41:29) GLP-1s and America's Obesity Epidemic (49:54) Rethinking vaccines from first principles (59:40) Lowering drug prices, the power of AI for healthcare (1:18:57) What causes autism? Follow Marty Makary...

United States
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Economy

Howard Lutnick: How America Can Hit 6% GDP Growth in 2026

(0:00) Commerce Secretary Howard Lutnick tells a hilarious Air Force One story (2:24) Chamath intros Secretary Lutnick (7:28) Full scope of the Commerce Department (12:59) How Trump's tariff agenda was planned and executed, how it's going (19:50) US-Japan trade deal, China's chaos-to-prowess strategy (36:54) Why the India deal has not yet happened (43:48) Pharma deals, lowering costs for Americans (53:28) Focus on fraud, immigration, gold cards (1:03:48) GDP: Could we see 5 or 6% growth in 20...

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Technology

Why AI will dwarf every tech revolution before it: robots, manufacturing, AR glasses from CES 2026

(0:00) Guest intros: Jasons introduces Bob Sternfels (McKinsey) and Hemant Taneja (General Catalyst) (2:52) The pace of innovation and why VC's are buying hospitals (9:30) CFOs vs CIOs and unlocking growth (20:46) The job market and why graduates aren't getting hired (27:33) Why education is broken (40:03) Tech time capsule Follow Hemant Taneja: https://x.com/htaneja Follow Bob Sternfels: https://www.linkedin.com/in/bob-sternfels Follow the besties: https://x.com/chamath https://x.com/Jason h...

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Business

Alex Rampell on Venture at Scale and Founder Incentives

This episode is a special feed drop from The Twenty Minute VC, featuring a conversation between Harry Stebbings and a16z General Partner Alex Rampell. Alex shares how he thinks about investing at scale, including why ownership and incentives matter, how venture changes as funds get larger, and what it really takes to win the best deals. He walks through his core founder framework of backing people who can materialize talent, capital, and customers, and explains why the strongest companies oft...

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Business

Ben Horowitz on TBPN: Three Decades with Marc and Building for the Long Game

Following the announcement of a16z’s new fund, Andreessen Horowitz cofounder and general partner Ben Horowitz joined TBPN to discuss how Andreessen Horowitz has evolved its firm structure as technology becomes embedded across every sector of the economy. Ben reflects on which lessons from The Hard Thing About Hard Things still apply to founders, why entrepreneurship remains difficult at any scale, and how long-term partnerships shape decision-making inside the firm. He explains the move towar...

Global
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Culture

Of Roots and Adventures

I have lived in Ohio, Michigan, Georgia (twice), Pennsylvania, Alabama (also twice), England, and Idaho. I left home to go to college, left another home to attend seminary, and. The post Of Roots and Adventures appeared first on First Things

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Society

Can Liberals Be Pronatalists?

Last year the United Nations Population Division predicted that global population will peak in approximately sixty years, at around 10.3 billion people. After that, the number of human beings will begin to fall. The post Can Liberals Be Pronatalists? appeared first on First Things

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Politics

Kemi puts the knife in first: Has sacking Jenrick made her stronger?

The politician who once complained of not seeing enough "white faces" in Birmingham probably had a very white one himself this morning. Robert Jenrick's apparent imminent plot to defect to Reform was left in tatters when his party leader Kemi Badenoch uncovered the plan, sacked him and booted him out of the party, and announced it to the world on a polished video clip. What happens now to the shadow justice secretary - as was - and to both the Tory party and Reform? Emily and Lewis speak to t...

United Kingdom
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